Sur le Web, ces 30 derniers jours

mardi 22 janvier 2019

  • Association of Aspirin Use for Primary Prevention of CVD With Cardiovascular Events and Bleeding
    This meta-analysis estimates the association between use of aspirin for primary prevention of cardiovascular disease and the rate of cardiovascular mortality, nonfatal myocardial infarction, nonfatal stroke, and bleeding.

  • Association Between Matched Sibling HSCT and Transcranial Doppler Velocities in Children With SCA
    This nonrandomized controlled intervention study compared the effect of matched sibling donor hematopoietic stem cell transplantation (HSCT) vs standard care comprising transfusions and hydroxyurea on transcranial Doppler velocities, a measure of cerebral vasculopathy, at 1 year in children (...)

  • Reforming Nutritional Epidemiologic Research—Reply
    In Reply The calculation of 12 years of life gained with the consumption of 12 hazelnuts daily (and similar calculations with other foods) was an argumentum ad absurdum. The estimation combined several prevalent assumptions and common practices to demonstrate how absurd inferences can arise. (...)

  • Cell-Free DNA Screening During Pregnancy—Reply
    In Reply In response to our JAMA Insights article on noninvasive prenatal genetic screening, Drs Cohen and Westover advocate for universal public and private reimbursement for cfDNA tests, arguing that it will reduce disparities in access to prenatal screening. Approximately 40% of US (...)

  • Reforming Nutritional Epidemiologic Research
    To the Editor The Viewpoint by Dr Ioannidis discussed the need for reform of nutritional epidemiologic research. We were surprised by the “nonexpert” calculations of gain or loss in life expectancy using data from our meta-analysis. We presented the findings in our meta-analysis as relative risks (...)

  • Cell-Free DNA Screening During Pregnancy
    To the Editor In the JAMA Insights Clinical Update on noninvasive prenatal screening using cfDNA, the authors discussed test failures that occur when the fraction of fetal DNA is too low, leading to a diagnostic test. The cited fetal fraction threshold of 4% is historical and modeled and (...)

  • Cell-Free DNA Screening During Pregnancy
    To the Editor Drs Allyse and Wick reviewed noninvasive prenatal genetic screening using cell-free DNA (cfDNA). We have concerns about some of their statements about the use of cfDNA screening and are disappointed that disparities in access were not discussed in greater (...)

  • Effects on Survival of Web-Based Symptom Monitoring vs Routine Surveillance After Lung Cancer Treatment
    This study reports 2-year survival outcomes among patients with advanced nonprogressive stage IIA to IV lung cancer randomized to symptom monitoring during chemotherapy via web-based patient-reported outcomes vs standard scheduled imaging after treatment to detect symptomatic (...)

  • Paleopathologic Studies
    Paleopathology, as we have pointed out, is a new word for a very old subject, which is only now beginning to attract the attention it deserves. All physicians interested in the scientific side of medicine, especially those who have professional and educational interests at heart, should be (...)

  • Highlights for January 22, 2019
  • Device for Cluster Headache
    The FDA has cleared a noninvasive vagus nerve stimulator as the first device indicated to help prevent cluster headaches in adults.

  • Saliva Swab for Diagnosing Congenital Cytomegalovirus
    A new type of diagnostic test to help detect cytomegalovirus infections in newborns within their first 3 weeks of life has received approval.

  • Drug Approved for Rare Muscle Weakening Syndrome
    More than 3 decades after its clinical use was first described, amifampridine has received approval for adults with rare, debilitating Lambert-Eaton myasthenic syndrome (LEMS).

  • Clinical Considerations for Aspirin Use for Primary Prevention in 2019
    Reducing platelet activity with aspirin and other antiplatelet agents is an important factor in the prevention and management of atherothrombotic vascular events. For this indication, aspirin has both beneficial and potentially harmful effects; it can diminish or reverse thrombus formation (eg, (...)

  • Matched-Sibling Stem Cell Transplantation and Stroke in Children With SCA
    Stroke is one of the most devastating complications of sickle cell anemia (SCA), and risk of stroke starts very early in life. Before screening techniques were available, 11% of children with homozygous SCA had ischemic stroke by their 20th birthday. Although most children with SCA will have (...)

  • Addiction 101, in Technicolor
    The Arts and Medicine feature reviews the film Beautiful Boy, a dramatization of journalist David Sheff’s 2008 memoir about his son’s descent into methamphetamine addiction and his tentative recovery.

  • Curbing Unnecessary and Wasted Diagnostic Imaging
    In this Viewpoint, Ioannidis and coauthors compare overuse of computed tomography and magnetic resonance image scanning with large-scale haphazard population screening for disease and call for dedicated investigations to understand how to reduce unnecessary and wasteful diagnostic (...)

  • Medicaid Expansion After the 2018 US Midterm Election
    This Viewpoint discusses the likelihood of Medicaid expansion in Maine, Wisconsin, Utah, and Kansas, where 2018 midterm voters elected candidates supportive of expansion or voted for it in ballot initiatives, and reviews evidence on associations between state Medicaid expansion and improved (...)

  • For Women, Sexual Harassment and Assault Is Associated with Poorer Health Years Later
    This Medical News article is an interview with Rebecca Thurston, PhD, about her recent study published in JAMA Internal Medicine that found sexual harassment and assault was associated with poorer midlife health in women.

  • Title X: Moving Forward or Backward on Women’s Health?
    Twenty years ago, the Centers for Disease Control and Prevention (CDC) declared family planning and contraception services as 1 of 10 great public health achievements in the United States in the 20th century. Access to contraception is associated with reductions in teen pregnancy rates, (...)

  • Malar Rash and Polyarthritis
    A 58-year-old woman had a 2-week history of right knee, right ankle, and bilateral finger joint pain with a facial rash after a febrile illness in her daughter and preschool grandchildren, and an ANA level elevated to 1:160 (homogeneous pattern; (...)

  • Friendships Across Cultural Barriers—We Are All the Same
    In this narrative medicine essay, a family practitioner tells the story of how her relationship with an old order Mennonite woman whose newborn son she examined and took to the hospital for cardiac surgery one Christmas day turns to friendship and a relationship with her broader community when (...)

  • Social Determinants of Health in the Digital Age
    In this Viewpoint, Harlan Krumholz and colleagues discuss the promise that social media data hold for helping researchers better understand social determinants of health, and the challenges that must be overcome to reliably link social network data to clinical and health (...)

  • Random-Effects Meta-analysis
    This JAMA Guide to Statistics and Methods explains the difference between fixed and random effects in treatment effect estimates, and the rationale for using random-effects meta-analysis to determine treatment effects across randomized trials conducted in heterogeneous patients and (...)

  • Ebola and War in the Democratic Republic of Congo
    In this Viewpoint, Gostin and colleagues review recommendations developed by experts convened by Georgetown University on how the international community can respond to the 2018 Ebola outbreak in the Democratic Republic of Congo (DRC) in the midst of active conflict and insecurity from armed (...)

lundi 21 janvier 2019

vendredi 18 janvier 2019









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