Sur le Web, ces 30 derniers jours

mercredi 15 mai 2019

mardi 14 mai 2019

  • Kromeya adalimumab
  • Besremi ropeginterféron alfa-2b
    Besremi est un médicament utilisé pour traiter la polycythémie vraie chez les adultes qui ne présentent pas de symptômes d’hypertrophie de la rate. Chez les patients atteints de polycythémie vraie, le corps produit trop de globules rouges, ce qui peut entraîner un épaississement du sang et une (...)

  • Miglustat Dipharma - miglustat
    Miglustat Dipharma est un médicament indiqué dans le traitement des patients adultes atteints de la maladie de Gaucher de type 1 légère à modérée. Les patients atteints de cette maladie souffrent de l’absence d’une enzyme qui décompose un type de graisse appelé glucosyl-céramide, ce qui a pour (...)

  • TB at Record Low in US
    The latest CDC data suggest that tuberculosis (TB) rates have reached the lowest ever reported in the United States. However, these levels are still not low enough to eliminate TB domestically.

  • HIV Underdiagnosed
    About 80% of new HIV cases in 2016 stemmed from people who didn’t know they had HIV or were not receiving treatment, according to a CDC Vital Signs report.

  • JAMA
  • Management of Preexisting Diabetes in Pregnancy: A Review
    This narrative review summarizes the management strategies for diabetes before, during, and after pregnancy, focusing on optimization of glycemic control, nonteratogenic medication regimens, and careful attention to comorbid conditions to mitigate maternal and neonatal (...)

  • Listen to Your Heart: Alternate Strategies When Symptoms Don’t Match the Diagnosis
    In this narrative medicine essay, an infection diseases physician unconvinced of a stroke diagnosis listened to his own heart beat and accurately diagnosed mitral valve prolapse and reminds physicians to consider other possibilities when the symptoms don’t line up with the (...)

  • Love Poem Without Wheat
    If you can’t eat it I won’teat it, he says to my sisterwhen she tests positivefor celiac. Then they makeof themselves a small countryin North Jersey where wheatwill not grow, nor be bought,nor be baked into breador cake, and in their solidaritythey will no longer miss it.Already her spine has a (...)

  • Rib Fractures
    This JAMA Patient Page describes the symptoms and treatment of rib fractures.

  • Association Between Unrecognized OSA and Cardiovascular Events After Major Noncardiac Surgery
    This cohort study assesses the association between unrecognized obstructive sleep apnea (OSA) and 30-day risk of cardiovascular complications (myocardial injury, cardiac death, heart failure, thromboembolism, atrial fibrillation, and stroke) among adults undergoing major noncardiac (...)

  • Association of a Beverage Tax With Price and Sales of Sugar-Sweetened and Artificially Sweetened Beverages
    This study examines prices and sales of sweetened beverages before and after implementation of a excise tax in Philadelphia, intended to reduce unhealthful drink consumption, and compares it with sales in Baltimore, which did not institute the same (...)

  • Effect of Restricting Concurrently Open Records in an EHR on Wrong-Patient Order Errors
    This randomized trial compares the risk of wrong-patient orders in an electronic health record (EHR) configuration allowing 1 vs up to 4 concurrently open patient records.

  • Patient-Centered Performance Metrics—Reply
    In Reply While there is no doubt that social and behavioral factors are central contributors to health, Dr Yunyongying and colleagues advance a false dichotomy between physician professionalism and patient-centered care. An acknowledgment that patient-related social and economic barriers are (...)

  • Acute Kidney Injury Related to Sepsis—Reply
    In Reply Dr Seres comments on the effect of low muscle mass on serum creatinine level. We agree that muscle mass and cachexia can decrease sensitivity of serum creatinine to detect a drop in GFR and AKI. Recently, Yoo and colleagues reported overestimation of GFR in patients with cirrhosis and (...)

  • High-Flow Oxygen Therapy for Respiratory Failure in Immunocompromised Patients—Reply
    In Reply Dr Frat and colleagues suggest that a high proportion of patients died without being intubated. As mentioned in the article, at randomization, 4 patients had do-not-resuscitate orders and 28 had do-not-intubate orders. All other patients, including those in time-limited trials, (...)

  • Patient-Centered Performance Metrics
    To the Editor The Viewpoint by Dr Khullar and colleagues raised some important points about how organizations evaluate high-quality care. In particular, the authors highlighted a shift from individual physician performance metrics toward organizational metrics. This shift addresses one aspect (...)

  • Acute Kidney Injury Related to Sepsis
    To the Editor A JAMA Diagnostic Test Interpretation article addressed the test characteristics of serum creatinine in critically ill patients with sepsis. The authors presented a patient with pneumonia and septic shock who developed acute kidney injury (AKI) on day 3. They discussed serum (...)

  • Acute Kidney Injury Related to Sepsis
    To the Editor Drs Legrand and Kellum reviewed the interpretation of serum creatinine in a critically ill patient. However, they only included a glancing reference to muscle mass and did not discuss protein intake. Both factors affect the evaluation of renal function and may have been important (...)

  • High-Flow Oxygen Therapy for Respiratory Failure in Immunocompromised Patients
    To the Editor Dr Azoulay and colleagues compared the effects of standard oxygen vs high-flow oxygen therapy on mortality of immunocompromised patients with acute respiratory failure in the intensive care unit (ICU). Despite a study hypothesis favoring high-flow oxygen therapy, the 28-day (...)

  • Randomized Clinical Trial (RCT) Findings and Postpublication Metrics
    This study examined the association between RCT findings supporting or rejecting the trials’ experimental hypotheses and postpublication metrics reflecting scientific and public interest; namely, citations, Altimetric scores, and (...)

  • Narcotic Drug Addiction as Regulated by a State Department of Health
    By an act of the Pennsylvania General Assembly, session of 1917, concurrently with the United States Congress, the Harrison Narcotic Law, to all intents and purposes, was placed on the statute books of the commonwealth. Under the police power of the state, the department of health regulates the (...)

  • Democrats Ponder Options: Medicare for All, Medicare for More, or Strengthening the ACA
    How far the country—or at least the Democratic Party—has shifted “left” over the past decade is reflected in the increasing attention being given to proposals for “Medicare for all.” Although the specifics vary with individual proponents, Medicare for all is a single-payer system that would have been (...)

  • Highlights for May 14, 2019
  • Sugar-Sweetened Beverage Taxes
    Some cities in the United States and countries around the world are adopting taxes on sugar-sweetened beverages as part of efforts to address the global epidemic of obesity and noncommunicable diseases and to raise revenues to address societal needs. There is compelling rationale for taxing (...)

  • Unrecognized Obstructive Sleep Apnea and Postoperative Cardiovascular Complications
    In the United States, obstructive sleep apnea (OSA) affects 14% of adult men and 5% of adult women, with higher rates among obese individuals and older adults. The majority of individuals with OSA remain undiagnosed. Although OSA has repeatedly been associated with unfavorable long-term (...)

  • Restricting the Number of Open Patient Records in the Electronic Health Record
    Over the past decade, the percentage of hospitals with electronic health record (EHR) systems has increased from less than 10% to more than 90%, and the adoption curve in outpatient settings has been similar. This means that most clinical work in the United States and in other resource-rich (...)

  • Off-the-Shelf Bioengineered Blood Vessels Tested in Trials
    Bioengineered blood vessels for hemodialysis access successfully supported blood flow and evolved into native-like blood vessels in patients with end-stage renal disease (ESRD) participating in 2 phase 2 trials, according to new findings published in Science Translational Medicine. The (...)

  • AI Identifies Implanted Cardiac Devices
    Artificial intelligence software outperformed cardiologists in identifying cardiac rhythm devices on patient x-rays, researchers recently reported in the Journal of the American College of Cardiology: Clinical Electrophysiology. The tool was designed to quickly identify malfunctioning (...)

  • Novel Nanochip Paves Way for Early Ovarian Cancer Detection
    Currently, no ovarian cancer screening test with high sensitivity and specificity exists. In a recent proof-of-concept study published in Nature Biomedical Engineering, a uniquely designed microfluidic nanochip detected low levels of ovarian cancer–associated markers in blood. If validated in (...)

  • The Arts Dispel Medical Students’ Qualms About Dementia
    In this Medical News article, experts discuss how various arts program can help medical students see people with dementia in a positive new light.

  • Wild Health: Dogs and Bats and Chickens, Oh My!
    This Medical News feature explains how 3 disparate types of animals help researchers make medical discoveries.

  • Incorrect Values in Flow Diagram
    The Original Investigation entitled “Effect of a Workplace Wellness Program on Employee Health and Economic Outcomes: A Randomized Clinical Trial,” published in the April 16, 2019, issue of JAMA, had errors in the Abstract, Figure, and Additional Contributions section. In the Abstract, the number (...)

  • Long-lasting Consequences of Gun Violence and Mass Shootings
    In the wake of the suicides of 2 students who survived the 2018 Parkland, Florida, mass shooting, this Viewpoint reviews evidence about the long-term adverse psychological effects of mass shootings on survivors and their families and communities, and proposes that changes in mental health (...)

  • Health Insurance and Mobile Health Devices
    This Viewpoint reviews the ways health insurers are incentivizing the purchase of wearable health devices and using them to reward healthy behaviors, and discusses the potential benefits (eg, increased physical activity, improved coordination of care) and adverse consequences (eg, increased (...)

  • Building Trust in Clinician-Organization Relationships
    This Viewpoint reviews the sources of distrust between clinicians and the leadership of health systems they practice in, and proposes principles by which trust might be rebuilt, including competent leadership that is visible, available, and responsive; transparency and honesty in communication; (...)

  • Building Trust Between Policy Makers and Clinicians
    As part of a JAMA series on reestablishing trust in medicine, Don Berwick and colleagues review the clinical, financial, and emotional costs to physicians of regulatory burdens, and propose ways to better balance audit and trust including requirements for policy makers to experience the daily (...)

  • Diagnosis and Management of Crohn Disease
    This JAMA Clinical Guidelines Synopsis summarizes the 2018 American College of Gastroenterology (ACG) guideline on management of Crohn disease in adults.

  • What Are Polygenic Scores and Why Are They Important?
    This Genomics and Precision Health article explains the use and interpretation of polygenic risk scores for determining disease risk and emphasizes the gap between widespread availability of direct-to-consumer (DTC) genetic testing and the near absence of evidence validating the scores in (...)

  • Hyrimoz adalimumab
    Hyrimoz est un médicament qui agit sur le système immunitaire. Il est indiqué dans les cas suivants: • psoriasis en plaques (maladie provoquant l’apparition de plaques rouges et squameuses sur la peau); • rhumatisme psoriasique (maladie provoquant l’apparition de plaques squameuses rouges sur la peau (...)

  • Venclyxto (vénétoclax) : signal de sécurité issu de l’essai clinique évaluant le vénétoclax dans le traitement du myélome multiple - Point d'Information
    En mars 2019, l’ANSM a été informée d’un signal de sécurité issu d’un essai de phase III (étude BELLINI) en cours évaluant l’utilisation du bortézomib et de la dexaméthasone en association avec le vénétoclax 800 mg/j ou placebo chez des patients atteints de MM en rechute ou réfractaires. Les résultats d’une (...)

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